0839 - Resistance of the Blood-nerve Barrier in Peripheral Nerve to Mechanical Compression; Changes in the Vascular Permeability of the Peripheral Nerve Trunk, Dorsal Root Ganglia and Nerve Root

Introduction Disturbance of blood flow and intraneural edema due to mechanical compression by the surrounding tissues appear to be closely involved in the appearance of neurological symptoms when entrapment neuropathy affects the peripheral nerves. In generally, the peripheral nerve has the perineurium as a diffusion barrier and the blood-nerve barrier is also existing in the endothelial cells of the endoneurial microvessels. These barriers of the peripheral nerve protect and maintain the nerve fibers in a constant environment. (5) We studied the integrity of the blood-nerve barrier in peripheral nerves by using clips to compress the dorsal root ganglion containing the primary sensory neurons, the spinal nerve root through which the central branches of these neurons pass, and the peripheral nerve trunk through which the peripheral branches run.